Metastasis, the spread of cancer to distant sites, is the leading cause of cancer associated mortality with limited therapies to prevent the process. The overarching question in our lab is to understand how the scavenging and transport of metabolites influences metastasis. To address these questions, we use human patient samples, cancer cell lines coupled with animal modeling in zebrafish and mice. We additionally utilize high-throughput tools such as CRISPR-Cas9 genome-wide screening along with immunofluorescence staining, multicolor flow cytometry and molecular biology to uncover new mechanisms by which cancers achieve fitness to metastasize. Currently, we primarily study cutaneous melanoma, but we have pilot projects exploring hepatobiliary cancers in the Indian subpopulations.